2. Signaling Pathways
  3. GPCR/G Protein
  4. GnRH Receptor

GnRH Receptor

Gonadotropin releasing hormone receptor; GNRHR

GnRH Receptor

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The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10378
    GPR10 agonist 1
    		Agonist
    GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC50 values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity.
    GPR10 agonist 1
  • HY-P2419
    [Ala6]-LHRH
    		Agonist
    [Ala6]-LHRH is a synthetic luteinizing hormone-releasing hormone agonist, demonstrating effective stimulation of pituitary luteinizing hormone secretion. [Ala6]-LHRH enhances reproductive hormone regulation, contributing to fertility treatments. [Ala6]-LHRH plays a crucial role in managing conditions related to hormone imbalances.
    [Ala6]-LHRH
  • HY-16168AS
    Degarelix-d7
    		Antagonist
    Degarelix-d7 (FE 200486-d7 free base) is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
    Degarelix-d<sub>7</sub>
  • HY-P0056
    Histrelin
    		Agonist
    Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.
    Histrelin
  • HY-P3606
    GnRH Associated Peptide (1-24), human
    		Activator
    GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.
    GnRH Associated Peptide (1-24), human
  • HY-P4568
    (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
    (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
    (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
  • HY-115633
    Elagolix
    		Antagonist
    Elagolix is an orally active, highly effective, selective and non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis.
    Elagolix
  • HY-P3675
    LH-RH (4-10)
    		Activator
    LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes.
    LH-RH (4-10)
  • HY-P3671
    [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
    		Antagonist
    [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist.
    [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
  • HY-P4693
    (Ser(tBu)6,Azagly10)-LHRH
    (Ser(tBu)6,Azagly10)-LHRH is a potent aza-GLY analog.
    (Ser(tBu)6,Azagly10)-LHRH
  • HY-13673S1
    Goserelin-d7
    		Agonist
    Goserelin-d7 (ICI 118630-d7) is deuterium labeled Goserelin. Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
    Goserelin-d<sub>7</sub>
  • HY-P11181
    Chorionic Gonadotropin-beta (109-145) (human)
    Chorionic Gonadotropin-beta (109-145) (human) is the carboxyl-terminal part (109-145) of the human chorionic gonadotropin beta subunit. Chorionic Gonadotropin-beta (109-145) (human) can be used in the research of immune responses.
    Chorionic Gonadotropin-beta (109-145) (human)
  • HY-P3666
    [D-Phe2,6, Pro3]-LH-RH
    [D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist.
    [D-Phe2,6, Pro3]-LH-RH
  • HY-P4144
    Onvitrelin ucalontide
    Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model.
    Onvitrelin ucalontide
  • HY-P5897
    GnRH antagonist 3
    GnRH antagonist 3 (Compound 11) is a GnRH antagonist with an IC50 of 7 nM. GnRH antagonist 3 can be used in the research of hormone-dependent diseases.
    GnRH antagonist 3
  • HY-P0009B
    Cetrorelix diacetate
    		Antagonist
    Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
    Cetrorelix diacetate
  • HY-P2082
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH
    		Agonist
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a gonadotropin-releasing hormone (Gn-RH) agonist that has a dose-dependent inhibitory activity on progesterone secretion from cultured human granulosa cells.
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH
  • HY-W041308R
    DCOIT (Standard)
    		Agonist
    DCOIT (Standard) is the analytical standard of DCOIT. This product is intended for research and analytical applications. DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca2+ signaling cascades[1].
    DCOIT (Standard)
  • HY-P3317
    Azaline
    		Antagonist
    Azaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a KD value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions.
    Azaline
  • HY-115633S
    Elagolix-d9
    		Antagonist
    Elagolix-d9 is the deuterium labeled Elagolix. Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    Elagolix-d<sub>9</sub>
Cat. No. Product Name / Synonyms Application Reactivity